Cognomen Santiago Alexis (Santiago Alexis 
) , in the world, is a very rare family name. The cognomen Santiago Alexis is habitual in Chile, where it is a rare surname, and Spain, where it is a very rare surname. More frequently, Santiago Alexis is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Santiago Alexis | Spain, Peru, Ecuador, Chile, Colombia |